“How chromatin regulates the biophysical function of cells - learning from NETosis" - Neutrophils are innate immune cells critical for host defense again pathogens. To accomplish their tasks, neutrophils need to generate, transmit and withstand cell-scale physical forces which allow them to deform, rapidly move, and kill pathogen…

Engineered environments for cell fate decisions - The function of a cell is, in part, regulated by its surrounding tissue microenvironment. The chemical composition and mechanical properties of this environment provide essential cues that direct stem cells toward specific fates. In this talk, I will describe our efforts to design…

RNA regulation at the single molecule level: from nuclear organization to molecular activity: Cellular behavior depends on the activities of countless individual biomolecules. Compared to population-based methods, the ability to simultaneously perturb and analyze individual molecules provides a more direct and quantitative…

TITLEEngineering Synthetic RNA Controllers for Biosensing Gene Regulation and Targeted TherapiesABSTRACT     Synthetic RNA circuits are engineered to precisely control cellular information flow, with applications in biosensing, gene therapy, and biomanufacturing. To design and implement RNA-based input/output…