University of California, Riverside

Department of Bioengineering



2016-2017 Distinguished Speakers Series


Date

Speaker

Colloquium Title

October 19, 2016

Harvey Borovetz
Distinguished Professor of Engineering, Department of Bioengineering
University of Pittsburgh

Long-Term Mechanical Circulatory Support in Children
November 2, 2016 Hugh Rosen
Professor of Chemical Physiology
The Scripps Research Institute
Of Mechanisms And Molecules: From R01 To Intelligent Intervention In MS
January 18, 2017 Song Li
Chancellor Professor and Department Chair
Department of Bioengineerg
Department of Medicine
University of California, Los Angeles
Mechanobiology of Cell Reprogramming
January 25, 2017 Arjun Yodh
James M. Skinner Professor of Science
Director of The Laboratory for Research on the Structure of Matter (LRSM)
University of Pennsylvania
Biophotonics with Diffusing Light
April 5, 2017 Aleksander S. Popel
Professor, Department of Biomedical Engineering, School of Medicine
Johns Hopkins University
Systems Biology of Cancer – a Bioengineering Insight

All colloquium presentations are held on Wednesdays from 11:00-noon unless otherwise noted

borovetz_award

Dr. Harvey S. Borovetz receiving a thank you award from the Bioengineering Department for his contribution to cardiovascular studies(October 19, 2016)

popel_award

Dr. Aleksander S. Popel receiving a thank you award from the Bioengineering Department

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November 2, 2016

Hugh Rosen (Distinguished)

Hugh RosenProfessor of the Department of Chemical Physiology, The Scripps Research Institute

Title: Of Mechanisms And Molecules: From R01 To Intelligent Intervention In MS

Abstract: The lysophospholipid GPCR S1PR1 is a critical regulator of disease processes. Effective multi-point interdiction of difficult to treat autoimmune diseases Multiple Sclerosis and Ulcerative Colitis, with compelling clinical efficacy and safety, have been achieved using a novel therapeutic ozanimod, first discovered and synthesized at TSRI. This is the first New Chemical Entity to emerge from NIH Common Fund discovery efforts and reflects integrating chemistry, biology, structure and discovery to define and modulate control points in pathophysiology for the benefit of patients.

Biography: Dr. Hugh Rosen, MD, PhD has been Professor of The Scripps Research Institute since 2002. He received his MB.ChB (M.D.) from University of Cape Town and his D.Phil. (PhD) in Physiological Sciences at the Sir William Dunn School of Pathology at the University of Oxford as a Royal Commission for the Exhibition of 1851 Scholar. He was elected a Fellow of the Infectious Diseases Society of America, to the Association of American Physicians, a Fellow of the American Academy of Microbiology and to the Henry Kunkel Society. He was Associate Editor of Molecular Pharmacology (2006-14) and on the Editorial board of Journal of Biological Chemistry. He chaired the Molecular Libraries Screening Network Steering Group, a part of the NIH Roadmap, and was PI of the Scripps Research Institute Molecular Screening Center. He was Scientific Founder of Receptos, Inc., now acquired by Celgene, and a co-inventor of ozanimod, a treatment for multiple sclerosis and ulcerative colitis. He recently co-founded BlackThorn Therapeutics , an ARCH Ventures portfolio company. He is an independent director of Regulus Therapeutics since June, 2016. Prior to joining TSRI, Rosen served as Executive Director in Immunology, Rheumatology and Infectious Diseases at Merck Research Laboratories. He serves as Member of Scientific Advisory Board at ActivX Biosciences, Inc. His laboratory discovered a novel mechanism of Immuno-modulation through small molecule alteration of lymphocyte trafficking.

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January 18, 2017

Song Li (Distinguished)

Song LiChancellor Professor and Department Chair the of Department of Bioengineering and of Medicine, University of California, Los Angeles

Title: Mechanobiology of Cell Reprogramming

Abstract: It has largely been accepted that biophysical cues can regulate a variety of cell functions, including signal transduction from the cell membrane through the cytoplasm to the nucleus. The regulation of signaling molecules by biophysical factors represents the early responses of cells, which can lead to the activation of transcriptional factors resulting in differential gene expression and cell functions. On the other hand, recent studies have also demonstrated that biophysical factors have a long-term effect on phenotypic changes, modulating stem cell differentiation and cell reprogramming. The change of cell phenotype stems from the modulation of its epigenetic state, the “memory” of a cell. By using cell reprogramming into induced pluripotent stem cells and neurons as models, I will discuss how biophysical cues such as microtopography, substrate stiffness and fluid shear stress can modulate the cell reprogramming process, through either epigenetic modifications or transcriptional regulation. These findings will lead to new cell engineering approaches for the applications in regenerative medicine, disease modeling and drug screening.

Biography: Dr. Song Li got B.S. and M.S. from Beijing University, and had his Ph.D. and postdoctoral training at UC San Diego. He was a Professor of Bioengineering at UC Berkeley between 2001-2015, and he recently moved to UC Los Angeles in 2016. He is a Chancellor Professor and serves as the Chair of bioengineering department. His research is focused on stem cell engineering, mechanobiology and tissue engineering. His recent work help elucidate the mechanisms of cell reprogramming regulated by biophysical factors and the roles of stem cells in tissue regeneration. Dr. Li has published > 150 papers in various journals including Nature Materials, Nature communications, PNAS, etc. He is also actively involved in the translation of research findings to bioengineering applications. Dr. Li has been elected as a Fellow of American Institute of Medical and Biological Engineering, a Fellow of Biomedical Engineering Society, and a Fellow of the International Academy of Medical and Biological Engineering.

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January 25, 2017

Arjun Yodh (Distinguished)

Arjun YodhJames M. Skinner Professor of Science Director of The Laboratory for Research on the Structure of Matter (LRSM), University of Pennsylvania

Title: Biophotonics with Diffusing Light

Abstract: Functional diffuse optical monitoring of tissue is gaining momentum as a diagnostic in a variety of medical scenarios including functional activation and clinical studies of brain, cancer imaging and cancer therapy monitoring, and investigation of muscle disease. I will review the general problem of spectroscopy and imaging with diffuse light. Then I will describe some recent biophotonics research from my lab that is oriented towards non-invasive monitoring of cerebral hemodynamics in adult/pediatric populations through intact skull and towards imaging cancer.

Biography: Arjun G. Yodh is the James M. Skinner Professor of Science at the University of Pennsylvania (Penn) and Director of Penn’s Laboratory for Research on the Structure of Matter (LRSM) and its Materials Science Research & Engineering Center (NSF-MRSEC). His home department is Physics & Astronomy; he also holds an appointment in the Department of Radiation Oncology in the Medical School and is a member of the graduate group of the Department of Bioengineering. Yodh obtained his BSc from Cornell University in 1981 and his PhD from Harvard University in 1986. He then worked at AT&T Bell Laboratories as a post-doctoral associate. He joined the Faculty at Penn in 1988. Professor Yodh is an experimenter in the areas of soft condensed matter physics and biomedical optics. Yodh’s biomedical research is oriented towards diffuse optical imaging and monitoring of deep tissue physiology, i.e., millimeters to centimeters below the tissue surface. His laboratory carries out fundamental studies of light transport, image reconstruction and optical technology development; in parallel, the lab identifies relevant clinical problems and applies these methodologies therein. Current research explores the potential of these tools for functional imaging/monitoring in brain and breast, for monitoring tumor hemodynamics during cancer therapy, and for investigation of patients with critical limb ischemia. In soft matter science he is known for experiments manipulating, measuring and using entropic forces to control assembly in colloidal suspensions, for use of temperature-sensitive polymers and microgel spheres in studies of crystal phase transitions and glass micromechanics, for observations of ellipsoidal particles ranging from their Brownian motion to their affect on coffee-rings, and finally for research with lyotropic liquid crystals including carbon nanotube solubilization in water.

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More Information 

General Campus Information

University of California, Riverside
900 University Ave.
Riverside, CA 92521
Tel: (951) 827-1012

Department Information

Department of Bioengineering
205 Materials Science & Engineering

Hours: 8:00 AM - 5:00 PM
Tel: (951) 827-4303
Fax: (951) 827-6416
E-mail: big@engr.ucr.edu

Potential Undergraduate Students:
Undergraduate Admissions

Potential Graduate Students:
Professor Victor G. J. Rodgers

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