University of California, Riverside

Department of Bioengineering



Professor Palermo’s work is featured in the Journal of the American Chemical Society 2018 Young Investigators Virtual Issue.


Professor Palermo’s work is featured in the Journal of the American Chemical Society 2018 Young Investigators Virtual Issue.

August 20, 2018

The Journal of the American Chemical Society (JACS) featured our Assistant Professor of bioengineering Giulia Palermo’s research in its 2018 Young Investigators Virtual Issue released in July.

Her publication, “Protospacer adjacent motif-induced allostery activates CRISPR-Cas9,” was selected as one of 26 publications from young investigators featured in the special issue and highlighted in the cover of JACS with an artwork by the authors.

“This is a beautiful molecular dynamics study of how CRISPR-Cas9, the revolutionary new genome editing technology, is allosterically activated by a protospacer adjacent motif (PAM). Palermo's group shows that upon binding of PAM, a series of conformational changes are triggered, activating the Cas9 catalytic domains responsible for concerted cleavage of the two DNA strands. . . the study highlights the utility of theoretical studies in providing deep mechanistic insights that are simply not accessible experimentally,” said Professor Michelle Coote, associate editor for JACS. Hyperlink to special issue: here

Dr. Palermo

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University of California, Riverside
900 University Ave.
Riverside, CA 92521
Tel: (951) 827-1012

Department Information

Department of Bioengineering
205 Materials Science & Engineering

Hours: 8:00 AM - 5:00 PM
Tel: (951) 827-4303
Fax: (951) 827-6416
E-mail: big@engr.ucr.edu

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Potential Graduate Students:
Professor Victor G. J. Rodgers

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