University of California, Riverside

Department of Bioengineering



Professor Palermo published her work at Quarterly Reviews of Biophysics


Professor Palermo published her work at Quarterly Reviews of Biophysics

August 20,2018

By using molecular simulations, Dr. Palermo revealed in real time and at atomic level resolution the process of activation of the leading genome editing tool CRISPR-Cas9. The activation is shown to occour through a fascinating process by which the protein and the nucleic acids are "sensing", "regulating" and "locking" the catalytic HNH domain ultimately cleaving the DNA.

A movie of the simulation has been added on youtube: Watch here

To read more about this mechanism, refer to the original paper:

G. Palermo, J. S. Chen, C. G. Ricci, I. Rivalta, M. Jinek, V. S. Batista, J. A. Doudna and J. A. McCammon. Key role of the REC lobe during CRISPR-Cas9 activation by “sensing”, “regulating” and “locking” the catalytic HNH domain. Quarterly Review of Biophysics 2018, 51, e9.

Hyperlink to journal: here

Dr. Palermo

More Information 

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University of California, Riverside
900 University Ave.
Riverside, CA 92521
Tel: (951) 827-1012

Department Information

Department of Bioengineering
205 Materials Science & Engineering

Hours: 8:00 AM - 5:00 PM
Tel: (951) 827-4303
Fax: (951) 827-6416
E-mail: big@engr.ucr.edu

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Potential Graduate Students:
Professor Victor G. J. Rodgers

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