Traumatic Brain Injury and Alzheimer’s Disease: Vascular Perturbations - Emerging evidence suggests that traumatic brain injury (TBI) and Alzheimer’s Disease (AD) may share similar pathophysiology including long-term alterations in neurodegeneration and cognition. Vascular perturbations are evident in both neurological…

Decoding microbiome-dependent metabolite signaling and immune modulation in the kidney - The kidney plays a central role in clearing chemically diverse small molecules from the body, making it a key site of exposure to both endogenous and microbiome-derived metabolites. These exposures can shape disease progression, particularly…

“How chromatin regulates the biophysical function of cells - learning from NETosis" - Neutrophils are innate immune cells critical for host defense again pathogens. To accomplish their tasks, neutrophils need to generate, transmit and withstand cell-scale physical forces which allow them to deform, rapidly move, and kill pathogen…

Engineered environments for cell fate decisions - The function of a cell is, in part, regulated by its surrounding tissue microenvironment. The chemical composition and mechanical properties of this environment provide essential cues that direct stem cells toward specific fates. In this talk, I will describe our efforts to design…