University of California, Riverside

Department of Bioengineering



2018 - 2019 Colloquium


Date

Speaker

Title

October 3, 2018 Cheng Dong University Distinguished Professor, Department of Biomedical Engineering, Pennsylvania State University
October 10, 2018 Debiao Li Distinguished Speaker, Cedars-Sinai, USC
October 24, 2018 Ali Khademhosseini University Distinguished Professor, Department of Bioengineering, UCLA
October 31, 2018 Volkmar Heinrich Department of Biomedical Engineering, UC Davis
November 7, 2018 Jiandi Wan Department of Chemical Engineering, UC Davis
November 14, 2018 Wei Gao Department of Medical Engineering, Caltech
November 28, 2018 Joshua Wood Mouse Biology Program, UC Davis
December 5, 2018 Ravi Bellamkonda University Distinguished Professor, Department of Biomedical Engineering, Dean of Engineering, Duke University

All colloquium presentations are held in WCH 205-206 at 11:10am unless otherwise noted.

**click on each image to find out more about each speaker.

October 3, 2018

Cheng Dong

DongUniversity Distinguished Professor, Department of Biomedical Engineering, Pennsylvania State University

Title: Immune Cell-Mediated Cell and Drug Delivery Platform

Abstract: Efficient drug delivery strategies into solid tumors that target primarily malignant cells and avoid damaging healthy tissue are limited by the pharmacokinetics, solubility and specificity of the chemotherapeutic drugs. Drug delivery into brain tumors is significantly more challenging due to the presence of the blood brain barrier. Glioblastoma, with a 5-year survival rate of only 5% is the most aggressive type of brain tumor. Despite modern treatment techniques (e.g. chemotherapy, radiation, and surgical removal), the prognosis remains dismal. To address this clinical challenge, we designed a targeted drug delivery system using genetically modifiedchimeric antigen receptor (CAR)-T cells to target glioblastoma tumors and polymeric nanoparticles to encapsulate the therapeutic drug. Nanoparticles provide a great opportunity to develop a targeted delivery system that in conjunction with immune cells can specifically deliver drugs to brain tumors.

Biography: Prof. Dong received his Ph.D in Engineering Science and Mechanics in 1988 from Columbia University. He is currently a Distinguished Professor of Biomedical Engineering and Head of the Penn State Department of Biomedical Engineering. He has received several prestigious honors and awards, including the US National Science Foundation (NSF) Faculty Career Award, American Cancer Society Faculty Research Award, ASME Y.C. Fung Investigator Award, ASME Melville Medal, ASME Best Journal Paper Award, and BMES Harold Lamport Young Investigator Award. The major focus of Dr. Dong's research is to elucidate biomechanical, biophysical and biochemical aspects of cellular function in the circulatory systems, with particular interest in cell adhesion, cell migration, cell signaling, cellular biomechanics and multi-scale modeling of biological systems. Current research at Penn State University includes studies of micro- hemodynamics, coagulation, leukocyte rheology, intercellular and intracellular signaling, cancer immunology and metastases. In particular, he is investigating how fluid dynamics, adhesion kinetics and tumor microenvironment change leukocyte and/or endothelial immune functions which subsequently affect tumor cell extravasation in the microcirculation and subsequent metastasis. He is also collaborating with material scientist and neural science biologist on most-recent designs of immune cell-mediated nanoparticle and drug delivery targeting brain tumors.

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University of California, Riverside
900 University Ave.
Riverside, CA 92521
Tel: (951) 827-1012

Department Information

Department of Bioengineering
205 Materials Science & Engineering

Hours: 8:00 AM - 5:00 PM
Tel: (951) 827-4303
Fax: (951) 827-6416
E-mail: big@engr.ucr.edu

Potential Undergraduate Students:
Undergraduate Admissions

Potential Graduate Students:
Professor Victor G. J. Rodgers

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