Integrated Optofluidics for Biomedical Applications
Abstract: Light is a special form of energy. Its unique physical properties give engineers and scientists the possibility to create numerous enabling functional devices and instrument for biomedical applications. This presentation will cover several integrated optofluidics technologies developed in our group in the past decade. The first topic will focus on a suite of technologies for high throughput single cell manipulation, including optoelectronic tweezers (OET) that enables manipulating single cells with light beams of intensity 5 orders of magnitude less than conventional optical tweezers, nanoblade technologies that utilize short laser pulse induced nanoscale cavitation bubbles to create highly localized cell membrane disruption for high efficiency delivery of ultra-large sized cargo such as whole mitochondria, and a pulse laser activated cell sorter (PLACS) that enables high speed fluorescence activated cell sorter with a throughput higher than 20,000 cells/sec in the microfluidic environment. The second topic will focus on a recently developed flexible, multifunctional neural probe with ultra-large tunable stiffness for deep-brain chemical sensing and agent delivery
Biography: Dr. Pei-Yu Chiou received his Ph.D. degree in the Electrical Engineering and Computer Sciences Department from the University of California at Berkeley in 2005. He received his M.S. degree in the Electrical Engineering Department from UCLA and B.S. degree in the Mechanical Engineering Department from National Taiwan University in 1998. He was an assistant professor in the Mechanical and Aerospace Engineering Department at the University of California at Los Angeles (UCLA) between 2006~2011, associate professor between 2011~2015, and full professor since then. He is also a full professor in the Bioengineering Department in UCLA. His research interests focus on optofluidics, biophotonics, and flexible electronic and mechanical devices. He received the NSF CAREER award in 2008, UCLA MAE Teaching Award in 2014. He was elected to American Institute for Medical and Biological Engineering (AIMBE) fellow in 2016, Royal Society of Chemistry (RSC) fellow in 2017, and IEEE Fellow in 2018.