We Stand in Solidarity Against Racism
The Department of Bioengineering stands in solidarity with our students, staff and faculty against social injustice and acts of racism. We are shocked and saddened by the recent, brutal deaths of George Floyd, Ahmaud Arbery, Breonna Taylor, Nina Pop, Rayshard Brooks and others. Like many members of our community, we are frustrated that these deaths are only the most recent manifestations of long-standing racial inequality in this country.
The Department supports the call to action made by the Bourns College of Engineering.
• We acknowledge that systemic racism permeates and poisons all levels of academia.
• We affirm that the Department has zero tolerance for racism, institutional bias or acts of violence against Black members of our community.
• We are committed to supporting Black students and combating the bias and inequity they face.
• We are committed to critically examining our recruitment and retention efforts to better support Black students, faculty and staff.
We would also like to take this moment to recognize the essential contributions made every day by Black students, faculty and staff. They are part of the Bioengineering family, and the department would not be as strong today without their efforts.
Colloquium Speaker: Beth A. Lopour, Assistant Professor, Department of Biomedical Engineering, University of California, Irvine
Title: Computational markers for the diagnosis and treatment of epilepsy
Abstract: The diagnosis and treatment of epilepsy relies on visual interpretation of electrophysiological data in the form of scalp electroencephalography (EEG) or, in preparation for epilepsy surgery, intracranial EEG. While there is extensive knowledge of the visual appearance of EEG waveforms associated with epilepsy and seizures, these standard techniques are sometimes insufficient to make a definitive clinical recommendation. For example, following epilepsy surgery, roughly half of patients will fail to achieve seizure freedom, and 70-90% will remain on antiepileptic medications. This suggests that additional information is needed to accurately identify the seizure onset zone and choose a target for surgical removal. In such instances, computational analysis of human electrophysiological data presents an opportunity to develop novel markers of epilepsy to supplement standard visual analysis. These tools facilitate improvements in the diagnosis and treatment of epilepsy by providing objective metrics to aid clinical decision making and elucidating basic mechanisms of the underlying disease. Specifically, my lab has developed computational techniques for (1) Predicting and measuring treatment response using EEG-based functional connectivity in a type of pediatric epilepsy called infantile spasms, and (2) Improved localization of the seizure onset zone for epilepsy surgery planning using high frequency oscillations (80-500 Hz) in intracranial EEG. I will give an overview of these techniques and describe their potential to impact the clinical treatment of epilepsy.
Bio: Beth Lopour has been an Assistant Professor of Biomedical Engineering and Mechanical and Aerospace Engineering at the University of California, Irvine since 2013. She received her B.S. in Mechanical Engineering from Northwestern University in 2004 and her PhD in Mechanical Engineering from UC Berkeley in 2009, where her research focused on representations of sleep and epilepsy in a mean-field model of the human cortex. Dr. Lopour was then a UC President’s Postdoctoral Fellow in Neurobiology at UCLA, studying single neuron recordings in the epileptic human brain. Since joining UCI, she has focused on signal processing techniques for both invasive and noninvasive human electrophysiological data, developing novel methods and computational markers to aid in the diagnosis and treatment of epilepsy. Her efforts were recently recognized by the American Epilepsy Society when she won the Junior Investigator Research Award.