Engineered environments for cell fate decisions - The function of a cell is, in part, regulated by its surrounding tissue microenvironment. The chemical composition and mechanical properties of this environment provide essential cues that direct stem cells toward specific fates. In this talk, I will describe our efforts to design…

RNA regulation at the single molecule level: from nuclear organization to molecular activity: Cellular behavior depends on the activities of countless individual biomolecules. Compared to population-based methods, the ability to simultaneously perturb and analyze individual molecules provides a more direct and quantitative…