We Stand in Solidarity Against Racism
The Department of Bioengineering stands in solidarity with our students, staff and faculty against social injustice and acts of racism. We are shocked and saddened by the recent, brutal deaths of George Floyd, Ahmaud Arbery, Breonna Taylor, Nina Pop, and others. Like many members of our community, we are frustrated that these deaths are only the most recent manifestations of long-standing racial inequality in this country.
The Department supports the call to action made by the Bourns College of Engineering.
• We acknowledge that systemic racism permeates and poisons all levels of academia.
• We affirm that the Department has zero tolerance for racism, institutional bias or acts of violence against Black members of our community.
• We are committed to supporting Black students and combating the bias and inequity they face.
• We are committed to critically examining our recruitment and retention efforts to better support Black students, faculty and staff.
We would also like to take this moment to recognize the essential contributions made every day by Black students, faculty and staff. They are part of the Bioengineering family, and the department would not be as strong today without their efforts.
By using molecular simulations, Dr. Palermo revealed in real time and at atomic level resolution the process of activation of the leading genome editing tool CRISPR-Cas9. The activation is shown to occour through a fascinating process by which the protein and the nucleic acids are "sensing", "regulating" and "locking" the catalytic HNH domain ultimately cleaving the DNA.
A movie of the simulation has been added on youtube: Watch here
To read more about this mechanism, refer to the original paper:
G. Palermo, J. S. Chen, C. G. Ricci, I. Rivalta, M. Jinek, V. S. Batista, J. A. Doudna and J. A. McCammon. Key role of the REC lobe during CRISPR-Cas9 activation by “sensing”, “regulating” and “locking” the catalytic HNH domain. Quarterly Review of Biophysics 2018, 51, e9.
Hyperlink to journal: here