Professor Palermo published her work at Quarterly Reviews of Biophysics
By using molecular simulations, Dr. Palermo revealed in real time and at atomic level resolution the process of activation of the leading genome editing tool CRISPR-Cas9. The activation is shown to occour through a fascinating process by which the protein and the nucleic acids are "sensing", "regulating" and "locking" the catalytic HNH domain ultimately cleaving the DNA.
A movie of the simulation has been added on youtube: Watch here
To read more about this mechanism, refer to the original paper:
G. Palermo, J. S. Chen, C. G. Ricci, I. Rivalta, M. Jinek, V. S. Batista, J. A. Doudna and J. A. McCammon. Key role of the REC lobe during CRISPR-Cas9 activation by “sensing”, “regulating” and “locking” the catalytic HNH domain. Quarterly Review of Biophysics 2018, 51, e9.
Hyperlink to journal: here